DNA 이중나선파손의 수복 과정과 이와 연관된 두경부암 발생 유전자
PATHWAYS AND GENES OF DNA DOUBLE-STRAND BREAK REPAIR ASSOCIATED WITH HEAD AND NECK CANCER
오정환, 이덕원, 류동목,
소속 상세정보
오정환 ( Oh Jung-Hwan ) - 경희대학교 치의학전문대학원 구강악안면외과학교실
이덕원 ( Lee Deok-Won ) - 경희대학교 동서신의학병원 치대병원 구강악안면외과
류동목 ( Ryu Dong-Mok ) - 경희대학교 동서신의학병원 치대병원 구강악안면외과
KMID : 0355620090350010001
Abstract
DNA double-strand breaks (DSBs) occur commonly in the all living and in cycling cells. They constitute one of the most severe form of DNA damage, because they affect both strand of DNA. DSBs result in cell death or a genetic alterations including deletion, loss of heterozygosity, translocation, and chromosome loss. DSBs arise from endogenous sources like metabolic products and reactive oxygen, and also exogenous factors like ionizing radiation. Defective DNA DSBs can lead to toxicity and large scale sequence rearrangement that can cause cancer and promote premature aging. There are two major pathways for their repair: homologous recombination(HR) and non-homologous end-joining(NHEJ). The HR pathway is a known“ error-free”repair mechanism, in which a homologous sister chromatid serves as a template. NHEJ, on the other hand, is a“ error-prone”pathway, in which the two termini of the broken DNA molecule are used to form compatible ends that are directly ligated.
This review aims to provide a fundamental understanding of how HR and NHEJ pathways operate, cause genome instability, and what kind of genes during the pathways are associated with head and neck cancer.
키워드
DNA double-strand breaks(DSBs);Homologous recombination(HR);Non-homologous end-joining(NHEJ);Cancer
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